A pause or block in progression through the cell cycle. It can permit repair or become durable; arrest is not itself proof that molecular damage has been repaired.
A durable cell state involving proliferative arrest and additional cellular changes. Its secretory effects can influence immune clearance and neighbouring tissue, so arrest and tissue-level benefit should be assessed separately.
A cyclin-dependent-kinase inhibitor induced in many p53-dependent arrest responses. Lower kinase activity helps restrain proliferation while stress is assessed.
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