Using accumulated CRISPR-induced sequence changes as inherited records of ancestry. Nested scars support a lineage tree only after considering recurrent edits, deletion of earlier scars and missing observations.
A lineage-recording approach coupling inherited CRISPR barcode edits with single-cell transcriptomes. It can relate cell identity to developmental ancestry while retaining the limitations of incomplete barcode recovery and edit homoplasy.[ref]

Ancestors (5)

  1. Genetic lineage tracing
  2. Cell lineage
  3. Biological cell
  4. Biology
  5. Home

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