Diane Rebourcet is a researcher in reproductive biology whose experimental work examines interactions between cells in the testis. In a 2014 collaborative study, Diane Rebourcet and colleagues investigated whether adult Sertoli cells support other testicular functions as well as developing reproductive cells. They engineered mice so that Sertoli cells expressed a receptor making them susceptible to a selectively administered toxin.[ref]
Selective cell ablation was followed by loss of reproductive cells and a roughly 75 percent decline in adult Leydig cell numbers. Removing one population and observing another gives stronger evidence for a functional dependency than simply finding both populations together. The result shows that adult Sertoli cells help maintain the Leydig cell population in this mouse model; it does not, by itself, distinguish direct cell contact from an indirect signal or establish a human treatment.[ref]
Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis by Diane Rebourcet and others. Abstract and Results: Sertoli-cell loss, Leydig-cell counts and retained tubular architecture
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