The epidermis is the outer stratified epithelial layer of the skin. Basal cell production and progressive differentiation maintain the outer barrier, including the stratum corneum. Production, upward movement and shedding must balance for stable tissue thickness.
The stratum corneum is the outer barrier layer of the epidermis, composed of highly differentiated flattened cells and associated extracellular lipids. Its organization restricts water loss and external entry. Barrier performance depends on the arrangement of both cellular and lipid components.
Loss of adhesion between epidermal cells. It is one mechanism of intraepidermal blister formation.
epidermis between hair follicles. Its renewal dynamics and lineage contributions vary with anatomical site and injury context.
A historical organizational model linking a spatial column of differentiated cells to a local basal renewing unit. Spatial appearance alone does not establish its lineage hierarchy.

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