A closed chain of Dirac propagators is a fermion loop. Its closed fermion loop sign distinguishes it from a bosonic loop. Tracing spinor indices produces gamma matrix traces, and the high-momentum powers of the propagators determine possible ultraviolet divergences.
Four scalar Yukawa interactions on a closed fermion loop generate a scalar four-point one-particle-irreducible vertex. At high momentum four dirac propagators contribute , leaving a logarithmic four-dimensional ultraviolet divergence. Its local scalar-fourth-power term requires a quartic scalar coupling; scalar mass and field counterterms cannot cancel it.
A closed fermion loop carries an additional minus sign from the odd Grassmann parity of the fields in the Wick theorem contraction expansion. Equivalently, integrating out Grassmann fields gives a determinant, whose logarithmic interaction expansion has the fermionic sign relative to a bosonic inverse determinant. This sign must be included in addition to propagator and vertex phases.
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