G. L. Hammond investigated how circulating binding proteins influence access to steroid hormones. A 1990 study examined corticosteroid-binding globulin, a blood plasma protein that binds cortisol, and its interaction with neutrophil elastase.[ref]
A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils by G. L. Hammond and others. Journal of Clinical Endocrinology and Metabolism 71, pp. 34–39; Abstract
In the assay, neutrophil elastase cleaved corticosteroid-binding globulin near its terminal region and released more than 80% of its bound cortisol. The cleavage did not inhibit the enzyme. The work supplied a molecular mechanism by which a hormone-binding carrier can change local hormone availability, while the proposed physiological delivery role requires distinguishing an experimental mechanism from its magnitude in living tissue.[ref]
A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils by G. L. Hammond and others. Abstract; proteolytic cleavage, steroid release and lack of elastase inhibition
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