An elevated propensity to acquire changes in nucleotide sequence, chromosome structure or chromosome number. A fixed alteration alone does not demonstrate a high ongoing alteration rate.
A clustered chromosome-rearrangement pattern associated with fragmentation and reassembly. It is one route to complex structural alteration, not a name for every rearranged genome.
A repeating sequence of chromosome-end fusion, bridge formation and breakage during division. Inadequate end protection can perpetuate structural changes and copy-number alterations.
Variation in short-repeat lengths resulting from inadequately corrected replication errors, commonly associated with defective DNA mismatch repair.
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