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A flavor-changing neutral current changes fermion flavor without changing electric charge. Such currents are absent at tree level in the Standard Model and are strongly suppressed at loop level by the Glashow-Iliopoulos-Maiani mechanism.

A leading short-distance Standard Model contribution to neutral D-meson mixing is a box Feynman diagram with two W bosons and two internal down-type quark lines:

The incoming $c\bar{u}$ pair becomes $u\bar{c}$; the internal labels run over the down quark, strange quark and bottom quark. Each corner is a weak charged current vertex. Four such vertices make the contribution of order $g^4$. Summing the internal flavours produces Cabibbo-Kobayashi-Maskawa matrix factors and the Glashow-Iliopoulos-Maiani mechanism: the flavour-independent term cancels by ${\sum }_i{V}_{ci}^{\ast }{V}_{ui}=0$. This box Feynman diagram is one contribution; long-distance intermediate hadron states can also contribute to neutral D-meson mixing.