Past exam of the mathematics course of the University of Cambridge 2001 iii Paper 28 4 a Solution Created 2026-10-03 Updated 2026-10-14
The survival estimates favor the new treatment at the two reported times, with absolute survival differences at two years and at five years. These point differences alone do not establish efficacy. Randomization supports a causal comparison of the treatment assignments, but sampling variance, censoring, follow-up, protocol adherence and the prespecified endpoint still matter. One should not infer a statistically established benefit merely from two larger estimates.
A Kaplan–Meier estimator iswhere is the risk set and the event count. Its uncertainty depends on the actual risk sets, not just the initial group size. The Greenwood formula estimatesWithout the missing survival tables one cannot calculate these standard errors or the uncertainty of the group difference. In particular, replacing the estimator variance by the variance of an uncensored binomial proportion would generally be wrong.
I would advise presenting both curves with numbers at risk and confidence intervals, checking independent censoring, and reporting a prespecified overall comparison plus an effect estimate and interval. For an unadjusted log-rank test, write and . Its hypergeometric null variance isTerms with no possible variation contribute zero. This compares the entire event history rather than selecting two arbitrary times, uses the available risk sets, and avoids choosing favorable time points after examining the curves. It is especially effective under proportional hazards. Crossing curves can make a log-rank comparison insensitive; a prespecified restricted mean survival time difference or another suitable time-varying analysis may then be more informative. An overall comparison does not make a clinically important prespecified time-point contrast invalid.
The Kaplan–Meier median survival time is the first event time at which . Monotonicity of the reported estimates impliesIf the new-treatment curve never reaches one half during observed follow-up, its median is not estimable from that curve. The exact crossing times cannot be reconstructed from two survival probabilities: the standard curve could first cross at three or at four years and still have the same values at two and five years. The point estimates suggest benefit, but the evidence and exact medians require the missing event/censoring tables. Neither a conclusive agreement nor a conclusive rejection of benefit is justified from these numbers alone.
Past exam of the mathematics course of the University of Cambridge 2008 iii Paper 41 5 b i Solution Created 2026-10-03 Updated 2026-10-14
Statistician B uses the more appropriate analysis. Its start–stop representation includes left truncation as well as right censoring. Both entry and exit are ages since opening, so a business belongs to the risk set at age only when . The event indicator distinguishes closure from a censored end of observation. The counting-process representation does not mean that multiple closures per business have been observed.
Statistician A records only exit and status and treats every sampled business as at risk from opening. That incorrectly adds already-established businesses to risk sets at ages before they entered observation, ignoring their necessary survival to entry. Its first risk count is , whereas B's is . The extra non-events dilute early estimated closure hazards and here bias the estimated survival upward. Correcting left truncation makes later risk sets capable of increasing as businesses enter at their respective ages.
For the Kaplan–Meier estimator with delayed entry, at event ages with closures and businesses at risk,The standard error follows from the Greenwood formula. Between event times this survival function estimate is constant. At age five the last preceding event is at , and at age ten it is at . Thus the requested estimates, including their precision, areandThese correspond to estimated proportions 46.2% and 28.0%, not to the probability of surviving five or ten additional years conditional on being sampled at an arbitrary age. A's corresponding estimates and use the inappropriate risk sets.
This interpretation assumes appropriately independent entry and censoring and a suitable common lifetime distribution across entry cohorts. A delayed-entry correction does not remove arbitrary informative sampling or calendar effects. More generally, if no observation covers the earliest ages, absolute survival from opening requires additional information about survival before the first observable age; the reported product-limit normalization is the one used in the supplied analysis.