A factor accelerating release of bound guanine nucleotide from a target protein, permitting reloading from the free pool. It does not phosphorylate bound GDP into GTP.
Eukaryotic exchange machinery promoting GDP release from eEF1A and reloading with GTP for another elongation cycle.
The bacterial exchange factor for EF-Tu. It lowers nucleotide affinity, enabling GDP release and subsequent GTP binding.

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