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Incoming links: Heart development
Emma de Pater Created 2026-10-20 Updated 2026-11-05
A developmental biologist who used fluorescent timing and photoconversion to distinguish phases of cardiomyocyte differentiation during zebrafish heart development.[ref]
Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart by Emma de Pater and others. Authorship and experimental findings
Fabienne Lescroart Created 2026-10-20 Updated 2026-11-05
A developmental biologist who used timed clonal labeling of Mesp1 progenitors to investigate regional lineage restriction during heart development.[ref]
Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development by Fabienne Lescroart and others. Authorship and experimental findings
Heart development Created 2026-10-20 Updated 2026-11-05
Heart development produces the pumping organ, its chambers, lining and supporting structures through coordinated differentiation and morphogenesis. The early heart tube changes shape through cardiac looping and receives further cellular contributions; changes in shape, cell number and cell identity are separable processes.
In zebrafish, fluorescent developmental-timing assays and a photoconvertible fluorescent protein distinguished early differentiation from later addition at the arterial pole of the heart. These experiments showed why growth of the heart cannot be explained solely by division of already differentiated cardiac cells.[ref]
Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart by Emma de Pater and others. Summary; transgenic timing and photoconversion assays
NKX2-5 Created 2026-10-20 Updated 2026-11-05
A homeodomain transcriptional regulator involved in cardiac specification, progenitor regulation and subsequent heart development. Early and late perturbations can test different functions.