In the Pseudomonas aeruginosa branchpoint discussed here, IDH denotes the isocitrate dehydrogenase activity insensitive to AceK phosphorylation and regulated allosterically by metabolic effectors. The abbreviation is context-dependent across organisms.
A cytosolic isocitrate-dehydrogenase isoform. Certain cancer-associated variants acquire an altered catalytic activity producing 2-hydroxyglutarate.[ref]
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate by Lenny Dang and others. Biochemical characterization of mutant enzyme
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