During this stage of the cardiac cycle, the ventricular inlet and outlet valves are both closed. Ventricular volume is fixed at its end-filling value , while increasing ventricular elastance raises pressure as . Arterial and venous pressures remain approximately fixed when the stage is short relative to their systemic resistance–compliance times.

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Isovolumetric contraction, also known as isometric contraction, is a phase of the cardiac cycle during which the ventricles contract but there is no change in their volume. This occurs after the ventricles fill with blood and when the pressure inside them rises significantly without any blood being ejected into the aorta or pulmonary artery.