Mechanism of activation of protein kinase JAK2 by the growth hormone receptor by Andrew J. Brooks and others

Andrew J. Brooks and colleagues, Science 344 (2014), 1249783, DOI 10.1126/science.1249783. Abstract: FRET measurement of JAK2-binding-motif positioning, engineered domain substitutions, transmembrane modeling and kinase/pseudokinase-domain arrangement. Mechanistic model rather than crystal observation of every signaling step.