Neocles B. Leontis studied RNA structure and molecular recognition at Bowling Green State University. His institutional profile identifies him as a chemistry professor and biology adjunct working on nucleic acids.[ref]
Neocles Leontis lifetime-achievement profile at BGSU. Research description and professional affiliation
With E. Westhof, Leontis proposed a systematic classification of RNA base-pair geometry using three possible interacting RNA base-pair edges and two relative glycosidic-bond orientations.[ref]
A small counting argument explains the12basic families. Write for the Watson–Crick, Hoogsteen and Sugar edges. Treating interchange of the two bases as the same edge-family givesThere are6unordered choices with repetition. Each can have cis or trans relative glycosidic-bond orientation, giving . This counts geometric families, not nucleotide sequences or the number of hydrogen bonds in every individual interaction.
The classification provides a way to annotate noncanonical base pairs and compare structural motifs. The2001 paper also explains how geometric families can reveal RNA base-pair isostericity, connecting observed structures to plausible substitutions in related sequences.[ref]
Geometric nomenclature and classification of RNA base pairs by N. B. Leontis and E. Westhof. Abstract, automated annotation and isosteric relationships
Neocles Leontis
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