Neutrophil extracellular trap

A neutrophil extracellular trap is an extracellular web containing chromatin and antimicrobial proteins released by activated neutrophils. The DNA-containing fibers can bind microbes and concentrate associated defensive components outside the cell. This differs from phagocytosis, in which a cell engulfs a target into an intracellular compartment.^[ref]

The original 2004 report described fibers that bound both Gram-positive and Gram-negative bacteria, degraded virulence factors and killed bacteria in the tested system. The structural observation and the functional measurement answer different questions: an image can show a bacterium associated with a web, while a viability assay tests whether the bacterium survives.^[ref]

A useful experimental comparison would measure trapping and survival separately, then test whether disrupting the DNA scaffold changes either endpoint. Such an intervention needs controls for effects on bacteria and neutrophils themselves. This is an illustrative design principle, not an additional protocol or numerical result attributed to the 2004 abstract.

The name describes a released structure; it does not by itself identify the complete pathway of release, establish that every neutrophil forms one, or prove that every trapped microorganism is killed. Distinguishing the web, its cellular production and its consequences keeps a morphological observation from becoming an unsupported universal mechanism.