An organoid is a three-dimensional cellular model that reproduces selected organized features of a tissue or organ. Its relevance depends on which cell types, architecture and functions it actually preserves, rather than on three-dimensional shape alone.
A cultured three-dimensional intestinal epithelial structure reproducing selected stem-cell and differentiation behaviours. Exogenous growth factors and matrix replace important environmental inputs, so successful growth does not demonstrate signal-independent development.
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