1 = AB, 2 = AC, 3 = BC. A and B are within the N-terminal portion of the chain and correspond to the darker, lower-error block. C lies in the later portion; the off-diagonal comparisons to it are paler and less confidently positioned.
The matrix reports predicted aligned error, not physical separation: a large matrix value does not mean that the two residues are far apart. It indicates uncertainty in their relative placement after alignment on one residue.[ref]

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