For a harmonic function , put . Its Wirtinger derivative is
so the Cauchy-Riemann equations make holomorphic. In the simply connected domain it has a single-valued primitive
The integral is path independent: local holomorphic primitives make its value invariant under path homotopies, and being simply connected makes any two paths with the given endpoints homotopic, as in Question 3.
Since , the real part satisfies and . Hence is constant on the connected domain. Adding a real constant corrects it, producing a single-valued holomorphic with . The imaginary part is a harmonic conjugate and is unique up to an additive real constant. This is the global harmonic conjugate criterion by vanishing periods in the simply connected case.
Take . In polar coordinates its Laplacian is , so it is harmonic on the annulus. If for a single-valued holomorphic function, the Cauchy-Riemann equations would give . But for ,
The first equality follows by evaluating the primitive around a closed curve. This contradiction verifies the absence of a global harmonic conjugate.
For the final function, the quotient of squared distances is . On , both and lie in the open right half-plane, so their principal logarithms are single-valued and holomorphic. Define
The series converges locally uniformly outside the unit circle, and
Thus this is the required single-valued holomorphic function, even on the larger domain . Its derivative is , whose two periods around the holes cancel. The logarithmic cancellation on an exterior annulus explains why this example succeeds while fails; using independent multivalued logarithms of and would conceal that cancellation.

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