Write and . Differentiating gives , so
In the independent exponential dispersion family, only depends on . Its derivative therefore gives the score function
The residuals are independent, have mean zero and variance . Consequently their score covariance is the Fisher information matrix:
This also equals minus the expected likelihood Hessian under the usual regularity conditions.
For the canonical link function, and , so
To obtain the maximum-likelihood estimate, solve , for example with Fisher scoring iterations . Equivalently use iteratively reweighted least squares, with weights and working response . Since , the common dispersion scale cancels from this update for . A nonsingular information matrix and a finite interior likelihood maximum are needed; iteration does not assert those for every possible dataset.

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