An affine variety is irreducible when it is nonempty and cannot be expressed as the union of two proper Zariski-closed sets. If a nonempty open subset were not dense, would be such a union: the first set is proper by assumption, and the second is proper because is nonempty. Hence every nonempty open subset of an irreducible variety is dense.
The coefficients of are polynomial functions of the matrix entries. Its polynomial discriminant is therefore a polynomial in those entries, and it is nonzero exactly when all roots of the characteristic polynomial are distinct. Thus the required set is the principal open subset of affine space. It is nonempty: an algebraically closed field is infinite, so choose a diagonal matrix with pairwise distinct entries.
It is also affine as a variety. The map identifies it with the closed hypersurface
Projection to is its regular inverse. This proves the requested affineness while retaining the open embedding into matrix space.
Each entry of is a polynomial in the entries of , so their simultaneous zero set is Zariski closed. A matrix in has distinct eigenvalues and is diagonalizable. If , then
Thus . Affine space is irreducible because its coordinate ring is an integral domain; by part (i), its nonempty open subset is dense. The closed set containing it must be all of affine space. This proves the Cayley-Hamilton theorem:

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