For a cylinder of radius and length , the mean curvature is and the area is . Its Helfrich membrane energy per unit length is thereforeThe first term favors a narrow tube and the second penalizes its curvature. Setting the derivative with respect to to zero givesThe positive second derivative confirms a minimum.
In the high-tension, narrow-gap regime, the almost spherical membrane has area . Its spherical bending energy is independent of radius, while Helfrich repulsion over area costsUp to terms independent of , a suitable free energy is consequentlyIts stationary point satisfiesUsing gives the fluctuation-supported membrane--particle gapThe inverse-square entropic repulsion prevents contact, while membrane tension limits the area gained by opening the gap.
Let measure distance across the narrow gap and let be polar angle about the tube axis. In lubrication theory, radial velocity and radial pressure variation are negligible. Axisymmetric incompressible flow is obtained frombecause . The tangential Stokes equation then separates:and hence, after choosing an irrelevant pressure constant,
In the sphere frame, . The no-slip boundary condition gives on the sphere and on the membrane translating backward relative to it. The sphere-frame volume flux inherited from the narrow remote tube is , soUnder the asymptotic condition , the right-hand side is negligible at leading order. Solving the quadratic profile subject to the two wall values and zero leading-order integral givesChanging the chosen positive tube direction reverses both signs but leaves the drag magnitude unchanged.
The pressure scale is , whereas the viscous shear scale is . After multiplication by comparable areas, pressure drag exceeds shear drag by , an instance of lubrication pressure dominates shear stress. Put . The axial pressure force isAs , the bracket tends to , and thereforeThe resulting confined-sphere drag coefficient isThus it exceeds the free Stokes drag law coefficient by . The Stokes–Einstein relation then gives
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