Minimize the residual sum of squares
Setting its three partial derivatives to zero gives the normal equations
These equations characterize the linear least squares minimizers, since is a convex quadratic. A unique coefficient vector additionally requires full column rank of the design matrix.
The centered regressors make the first normal equation read . Define
The remaining equations are and . Provided , matrix inversion gives
By the Cauchy-Schwarz inequality, . If , the two regressor columns are linearly dependent, and their separate slopes are not uniquely identifiable. One still has well-defined linear least squares fitted values, but cannot use the displayed divisions by .
If the two regressors are strongly associated, the data may provide little support for varying one while holding the other fixed. Multicollinearity makes the separate slope estimates unstable, and exact linear dependence makes them unidentifiable. A conditional slope may also be an extrapolation beyond combinations actually observed.
Furthermore, a slope in a linear regression model is not automatically a causal effect. A causal interpretation needs appropriate design or assumptions excluding confounding; independence of the errors across observations and zero mean alone do not establish those assumptions. The coefficients describe the specified linear mean relation, but changing a regressor by intervention can have a different interpretation.

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