Past exam of the medicine course of the University of Oxford / 1864 / Second examination / Therapeutics / 5

Bearing in mind the several causes of Uterine Hæmorrhage, what ought to be the treatment of the various forms of this affection ?

Resuscitate significant haemorrhage while identifying its cause; pregnancy, timing in relation to birth, and the condition of the uterus determine the definitive treatment. A vaginal loss need not originate in the uterus, and the visible volume may underestimate concealed bleeding. Assess consciousness, pulse, blood pressure and ongoing loss; serious bleeding calls for urgent obstetric or gynaecological help, intravenous access, blood sampling and access to blood transfusion. Investigations must not delay control of a life-threatening source.

Outside pregnancy, distinguish excessive menstrual bleeding from irregular, postcoital or postmenopausal bleeding. Causes include uterine fibroids, endometrial polyps, disturbed ovulation, coagulopathy and cancer. A speculum examination may reveal a cervical or vaginal source. History, examination, blood count, and appropriately selected ultrasonography, hysteroscopy or tissue sampling establish the cause. Current treatment for heavy menstrual bleeding may use tranexamic acid or hormonal treatment where suitable; removal of a polyp or treatment of a uterine fibroid addresses a structural cause. Suspected cancer needs a diagnostic and specialist pathway, rather than repeated empirical suppression of bleeding.^[ref]

In early pregnancy, consider threatened or established miscarriage and retained pregnancy tissue. Establish the location and viability of the pregnancy with ultrasonography and, where appropriate, serial human chorionic gonadotropin measurements. Stable cases permit a choice among expectant, medical or surgical management according to the diagnosis and circumstances; heavy ongoing bleeding or instability changes the urgency. An ectopic pregnancy may cause vaginal bleeding together with dangerous internal haemorrhage, even though the bleeding pregnancy is outside the uterus. Pain, collapse or instability therefore demands urgent assessment rather than an assumption that all bleeding represents a harmless menstrual or uterine event.^[ref]

Later pregnancy requires distinction between placenta praevia, placental abruption and other genital-tract sources. Placenta praevia may cause heavy painless bleeding; placental abruption may involve pain, a tense uterus and concealed loss. Stabilise the mother, assess the fetus and locate the placenta by ultrasonography. Avoid a digital examination that could disturb a covering placenta before placenta praevia has been excluded. The timing and route of birth depend on severity, placental position, gestation and maternal and fetal condition. A placenta covering the cervical opening usually requires Caesarean section; the diagnosis is not an instruction to apply a vaginal plug and wait through major continuing loss.^[ref][ref]

During and after birth, organise postpartum haemorrhage causes as poor uterine contraction, retained tissue, genital-tract trauma and defective clotting. A uterine rupture is a surgical emergency; a contracting uterus does not exclude a traumatic source. For uterine atony, uterine massage and a suitable uterotonic accompany resuscitation; emptying a distended urinary bladder may help contraction. Examine for tears and repair them; deal with retained placental tissue with skilled obstetric care, and do not forcibly detach an abnormally adherent placenta. Correct relevant coagulopathy and use blood products as indicated. Current early treatment includes tranexamic acid within the recommended interval. Continuing bleeding may require balloon tamponade or surgery; a uterine inversion requires urgent skilled replacement and resuscitation, not treatment as simple atony. Delayed bleeding after birth suggests retained tissue or infection and requires renewed assessment.^[ref]

An 1864 practitioner could recognise miscarriage, abnormal placental attachment or separation, retained placenta, atony and traumatic bleeding, and could attempt pressure, manual measures and delivery appropriate to the cause. Cold applications and vaginal plugging appeared in period practice, but were not interchangeable cures. Contemporary obstetric discussion already distinguished several mechanisms of bleeding.^[ref] In particular, a uterotonic cannot repair a tear, and obstructing the outflow does not establish that internal haemorrhage has ceased. The modern diagnostic and resuscitative measures above explain why treatment must follow the mechanism rather than the symptom alone.