The totals are independent binomials, and . Thus
Differentiating the log likelihood, or maximizing the two factors separately, gives
This remains the constrained maximum at zero or one when a total is at an endpoint. At interior parameters the sample information, in coordinate order , is
For example ; the cross derivative is zero. As both sample sizes grow with nondegenerate interior probabilities, the joint approximation is normal with mean and covariance . The independence of the two estimators is exact, inherited from the two data samples.

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