Study of inherited variation relevant to psychiatric outcomes. Liability, developmental timing, symptoms and response to treatment are distinct phenotypes that can have partly different genetic influences.
A research consortium conducting large collaborative studies of psychiatric genetic variation. Formal subgroup authorship is retained in the relevant bibliography record.
A model in which a binary diagnostic outcome occurs when an underlying continuous liability exceeds a threshold. Genetic and environmental components can influence liability. Estimating liability-scale heritability requires assumptions about prevalence, ascertainment and the liability distribution; crude diagnostic concordance is not a continuous-trait correlation.
The inherited component of vulnerability to an outcome under a specified model and environment. Liability is probabilistic; genetic association does not imply inevitable disease or identify an individual's exact onset time.
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