Rabin8 is a guanine-nucleotide exchange factor that activates Rab8a by promoting exchange of bound GDP for GTP. It links upstream trafficking signals to a Rab-controlled membrane-delivery pathway, including ciliary membrane formation. Its role is distinct from a GTPase-activating protein, which accelerates GTP hydrolysis. The exchange factor changes the state of the molecular switch rather than carrying all cargo itself. [ref]

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