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Gain ranging changes the sensitivity of a measuring signal path to keep its output within a useful interval as the input changes. A high-sensitivity setting resolves smaller inputs; a lower-sensitivity setting accommodates larger ones before amplifier clipping. Combining the settings can extend the instrument's usable dynamic range, provided their input intervals overlap and their measurement calibration is consistent.

A concrete apparatus is a switchable transimpedance amplifier converting electric current into an output electric potential difference. The DLPCA-200 manufacturer diagram separates a current-to-voltage stage from programmable amplification, and its performance tables give gain-dependent noise, input limits and bandwidth. The settings therefore change more than the decimal point of a display.^[ref]

For an original ideal calculation, suppose two settings follow $V_j=G_{j}I+b_j+n_j$, where $I$ is input current, $b_j$ the offset and $n_j$ zero-mean output noise. Stipulate a usable offset-corrected output from $5\mathrm{mV}$ to $1\mathrm{V}$ in either setting. With $G_H=10^{8}V/A$, the input interval is $50\mathrm{pA}$ to $10\mathrm{nA}$. With $G_L=10^{6}V/A$, it is $5\mathrm{nA}$ to $1\mu \mathrm{A}$. Each setting spans a ratio 200, but their overlapping union spans a current ratio 20000. These are stipulated intervals, not specifications for the cited amplifier.

Range-overlap calibration checks that both settings estimate the same current in their common $5$–$10\mathrm{nA}$ interval. A range-switching hysteresis rule can switch down in sensitivity above $8\mathrm{nA}$ and back up below $6\mathrm{nA}$, reducing repeated switching near one boundary. The output must settle before it is accepted as a new measurement indication.

An analog-to-digital converter that merely changes its printed units cannot recover an already clipped upstream signal. Likewise, increasing amplification does not automatically improve input-referred noise; the new setting may have different noise sources, bandwidth and drift. A meaningful combined range includes these effects and the required measurement uncertainty, rather than multiplying nominal gain settings without checking their usable intervals.