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Joined 2026-09-21 Message
Incoming links: RNA-binding protein
Pumilio 2026-10-20
An RNA-binding protein that collaborates with Nanos and other factors in sequence-specific repression of target messenger RNAs.
Rajan Lamichhane Created 2026-10-20 Updated 2026-11-05
Bringing separated RNA segments into proximity while an intervening segment forms a loop. Multivalent RNA-binding proteins can stabilize this geometry, with consequences for accessibility and splice-site use.
RBFOX protein Created 2026-10-20 Updated 2026-11-05
A member of a family of sequence-selective RNA-binding proteins involved in regulating alternative splicing.
Sequence-selective binding near an alternative exon can change recruitment or activity of the splicing machinery. The same binding motif can be associated with different outcomes depending on position and the surrounding regulatory context. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapter 7, RNA Processing and Alternative Splicing
RNA looping Created 2026-10-20 Updated 2026-11-05
Bringing separated RNA segments into proximity while an intervening segment forms a loop. Multivalent RNA-binding proteins can stabilize this geometry, with consequences for accessibility and splice-site use.
Roger M. Wartell 2026-11-05
Roger M. Wartell is a biophysicist whose research connects nucleic-acid structure with physical measurements of folding and association. His Georgia Tech profile traces his training through physics degrees at Stevens and Rochester and identifies research on DNA melting, RNA-binding proteins and small RNA molecules in ice.[ref]
Roger Wartell profile at Georgia Tech. Biographical summary and research interests; linked CV, education and fields of interest
With Xueguang Sun and J. Michael Li, Wartell investigated a stable RNA hairpin that could form a metastable RNA dimer in frozen solution. Their study combined gel electrophoresis, sedimentation equilibrium and temperature-dependent absorbance to distinguish structures and their interconversion.[ref]
The scientific issue is broader than the existence of two gel bands. A band's electrophoretic mobility depends on molecular shape and experimental conditions as well as size. Independent measurements of association and thermal response help test whether the bands represent two folds of one strand or complexes containing different numbers of strands. Wartell's work illustrates how complementary physical measurements can constrain an otherwise ambiguous structural interpretation.