S-100 conserved domain record in NCBI CDD

Primary curated conserved-domain record cd00213: S-100 family alignment and conserved calcium-binding/dimerization features. Distinguishes the S100-specific N-terminal EF hand from the C-terminal canonical EF hand; structural evidence includes calcium-bound human S100A8 PDB1MR8. Family membership does not imply identical ligand occupancy or a single shared biological activity.