A scalar second-order differential operator is in Sturm–Liouville form when it is written as
possibly together with a positive weight in an eigenvalue problem.
The weighted operator , with real coefficients and in the interior, defines a Sturm-Liouville problem. Its realization as a self-adjoint differential operator requires a domain whose endpoint conditions annihilate the boundary form . Its Rayleigh quotient uses the weight in the denominator.
For and zero endpoint values, write with , and . The change of variable has and sends , . Thus it is an isometry from the weighted inner product to the ordinary integral on , and the apparent singular operator becomes . Its Dirichlet eigenvalues are and its normalized eigenfunctions are , . The singular endpoint is handled through this transformed regular domain; a zero eigenvalue occurs exactly when .
For continuous and bounded real , the form on the zero-trace Sobolev space defines the weak operator . Its literal operator domain is the displayed flux domain. If a weak solution has right-hand side , then , so it belongs to that domain. This avoids assuming that a merely differentiable coefficient has bounded derivative. With bounded away from zero, the domain reduces to .
For , direct differentiation gives . The potential terms cancel. Integrating with common homogeneous Dirichlet boundary conditions eliminates the endpoint term. If and , this gives , a necessary solvability condition for the inhomogeneous equation.

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