T. R. Kumar is the researcher who led a 1997 study of the function of follicle-stimulating hormone in mouse reproduction. The study used a gene knockout affecting the hormone-specific follicle-stimulating hormone beta subunit, producing mice deficient in the active hormone.[ref]
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility by T. R. Kumar and others. Byline and Abstract: targeted FSH-beta deficiency
The outcomes differed between sexes. Females were infertile because ovarian follicle development stopped before formation of an antral cavity. Males retained reproductive capability despite having reduced testis size. The experiment therefore distinguished a requirement for normal organ development from an absolute requirement for the measured reproductive endpoint.[ref]
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility by T. R. Kumar and others. Abstract: female preantral arrest and male fertility despite reduced testicular size
For example, observing an altered organ size and observing failure to produce offspring answer different questions. The same perturbation can affect both endpoints to different degrees. These mouse results established a specific experimentally tested distinction; they do not by themselves determine the outcome of every reduction in follicle-stimulating hormone in another species.
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