Tetrahedron volume under sliding opposite edges ($V=\frac{1}{6}|\Delta \cdot (a\times c)||\delta \lambda \delta \mu |$)

Place one pair of opposite tetrahedron vertices on the line $b+\lambda a$ and the other pair on $d+\mu c$, with fixed nonzero direction vectors $a,c$. Let $\Delta =d-b$ and let $\delta \lambda ,\delta \mu$ be the parameter differences within the two pairs. The scalar triple product of the three edge vectors from one vertex gives the displayed volume. Terms parallel to $a$ or $c$ vanish in the triple product, leaving only $\Delta \cdot (a\times c)$. Sliding either pair along its own line while preserving its separation leaves this volume unchanged. When the two lines are skew lines, it can also be written $V=d_{\perp }{\ell }_1{\ell }_2|\sin \alpha |/6$, where $d_{\perp }$ is their shortest distance, ${\ell }_1,{\ell }_2$ the two edge lengths and $\alpha$ their direction angle. Intersecting or parallel lines give zero volume because all four vertices are coplanar.