Two sites are enantiotopic if separately replacing one or the other by the same distinguishing group gives enantiomers. Achiral conditions do not distinguish them by chirality alone.
As of my last knowledge update in October 2023, "Topicity" does not refer to a widely recognized concept, organization, or term. It is possible that "Topicity" could refer to a niche subject, aspecific brand, or a newly emerging concept that gained traction after my last update.
