Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome by the Acute Respiratory Distress Syndrome Network (2000)

New England Journal of Medicine 342(18), 1301–1308 (4 May 2000), DOI 10.1056/NEJM200005043421801. Primary corporate byline Acute Respiratory Distress Syndrome Network. Abstract, Methods and Results: randomized comparison of lower versus traditional tidal-volume and plateau-pressure strategies in 861 patients. Volumes were indexed to predicted body weight. These are historical trial protocols, not individual ventilator-setting recommendations.