Ciro Santilli @cirosantilli 40

The definition does not include homonuclear molecules which is a pain.

Bibliography:

As of 2018, Ciro Santilli believes that this could be the next big thing in biology technology.

"De novo" means "starting from scratch", that is: you type the desired sequence into a computer, and the synthesize it.

The "de novo" part is important, because it distinguishes this from the already well solved problem of duplicating DNA from an existing DNA template, which is what all our cells do daily, and which can already be done very efficiently in vitro with polymerase chain reaction.

Many companies are attempting to create more efficient de novo synthesis methods:

Notably, the dream of most of those companies is to have a machine that sits on a lab bench, which synthesises whatever you want.

TODO current de novo synthesis costs/time to delivery after ordering a custom sequence.

The initial main applications are likely going to be:but the real pipe dream is building and bootstraping entire artificial chromosomes

News coverage:

Applications:

If you are a pussy and work a soul crushing job, this is one way to lie to yourself that your life is still worth living: do one cool thing every day.

Find a time in which your mind hasn't yet been destroyed by useless work, usually in the morning before work, and do one thing you actually like in life.

Work a little less well for you boss, and a little better for yourself. Ross Ulbricht:Selling drugs online is not advisable however.

Even better, try to reach an official agreement with your employer to work 20% less than the standard work week. For example, you could work one day less every week, and do whatever you want on that day. It is not possible to push your passion to weekends, because your brain is too tired. "You keep all non-company-related IP you develop on that time" is a key clause obviously.

On a related note, good employers must allow employees to do whichever the fuck "crazy projects", "needed refactorings or other efficiency gains" and "learn things deeply" at least 20% of their time if employees want that: en.wikipedia.org/wiki/20%25_Project. Employees must choose if they want to do it one day a week or two hours per day. One day per month initiatives are bullshit. Another related name: genius hour.

Highly relevant on this topic: Video "What Predicts Academic Ability? by Jordan B Peterson (2017)".

Maybe you will be fired, but long term, having tried, or even succeeded your dream, or a one of its side effects, will be infinitely more satisfying.

The same goes for school, and maybe even more so because your parents can still support you there. Some Gods who actually followed this advice and didn't end up living under a bridge:

Gandhi TODO source:

Best quote at 00:23:01: matters of small concern should be treated seriously.

Ciro Santilli is actively looking for donations and contracts so he can continue to work full time on OurBigBook.com sustainably, and develop free hardcore university-level STEM education for all ages!

For 400k USD I will quit my job or not get a new job and work on OurBigBook full time for a second year to try and kickstart The Higher Education Revolution. Status: ~44k / 300k USD. At 4M USD I retire and work on open STEM forever. More realistically perhaps would something like 800k USD for four years like the MacArthur fellowship wink.

I first quit my job 1st June 2024 to work on the project for 1 year after I reached my initial 100k goal mostly via a 1000 Monero donation. In this first year I improved project tech, but didn't go and solve university courses to create super targeted content, and didn't obtain a single contributing user except myself, see a summary at Section "OurBigBook Project Update March 2025". My last day job total compensation as of 2024 was about 150k USD/year.

For a followup, it would be an interesting experiment to spend on year full time solving as many courses as I can from a world class university in the city where I live in the UK, and adding that as content to the platform to see if that would attract interest, and reaching out directly to course takers at their university environment to try and help them. I intended to do that in year one but my got distracted by tech. It is quite possible that no one has ever done that before in history: a highly motivated technical person with the time and opportunity to do one single thing: help top university students learn their STEM courses better and have more fun doing so. I have in particular identified one course where this would be particularly feasible: the mathematics course, given that much of their course materials, and also their building are quite open. I do sometimes wonder if doing this would be just a waste of my life. But part of me tells me it could generate big interest and is worth a try. It would also be fun for you to watch me continue to commit career seppuku.

For a second follow up year, I increased my requirement to 400k USD to give me more peace of mind. So the total donation so far is 344k, and if I reach a total of 400k USD, then I'll work on the project for a second year.

At 4M USD I retire and work on open STEM projects forever. At these timelines, I can't guarantee it will be specifically on education technology specifically all the way, but I guarantee that whatever it is it will be open and extremely well explained as usual.

Total donations to date ~244k USD. Donation breakdown:More details: Section "Accounting method"

How to give:And if you have a different preferred payment mechanism not listed above, please contact Ciro, and he will set it up.

Ciro's current ambitions require him to remain in developed countries, because Ciro wants to document advanced science and technology by liaising with top universities, and there is not nearly as much high technology in poor countries. Remaining in developed countries is also a required due to family reasons.

Note to potential anonymous crypto donors: I live in the UK, and after some messy back and forth that included freezing my account at one point, Barclays finally decided that they do not allow me to receive anonymous donations. And I'm pretty sure that the same would happen on any other British bank sooner or later. Therefore, while I continue to accept anonymous donations, they will not count towards my "if I get X I do Y"-type donation goals, since I can't reliably spend that money. If you want to donate in crypto, and clearly give me your real identity and an explanation of how you got the money, then that is fine, it can count. Just be warned that I will need to give that information to my bank and clear it with them beforehand, and if they are still not happy with it, I'll just give it all back. Your identity does not have to be publicly disclosed, only the dates and amounts. But my bank has to know.

If you would like public acknowledgement for your support, Ciro will very gladly give it, just let Ciro know how you'd prefer it. Due to Ciro Santilli's campaign for freedom of speech in China, many supporters have chosen to be anonymous, and that is totally fine, not everyone is interested in politics, or has a situation where going public is acceptable, so we don't have a standard setup yet, let's build it together. A acknowledgement section at the bottom of this page would be a minimum, but I for larger donations we could add a your advertisement in a locations such as: