Ciro Santilli @cirosantilli  40

One of the most beautiful things in mathematics are theorems of conjectures that are very simple to state and understand (e.g. for K-12, lower undergrad levels), but extremely hard to prove.

This is in contrast to conjectures in certain areas where you'd have to study for a few months just to precisely understand all the definitions and the interest of the problem statement.

Bibliography:

UniProt human: www.uniprot.org/uniprot/Q9BYF1 It is interesting to see in the Mutagenesis how many known mutations can increase or decrease SARS-CoV-2 S protein binding affinity.

Receptor in SARS-CoV-2 cell entry.

Receptor in SARS-CoV-2 cell entry.

By Fred Sanger's group.

Published as: sequence and organization of the human mitochondrial genome by Sanger et al. (1981).

As mentioned by Craig Venter in 100 Greatest Discoveries by the Discovery Channel (2004-2005), the main outcomes of the project were:

Important predecessors:

This was one of the first notable country-led large scale sequencing efforts of the world.

Sample paper: www.nature.com/articles/ng.3247

This is really cool. Ciro Santilli would be tempted to participate, but his wife is not a fan, in part due to the loss of privacy of children. Maybe she is right...

Someone should implement a version of that where you can upload your privately sequenced genome and get analytics for free.

The point of these is that they are good for transfection apparently.

This was the first large part of the genome that was sequenced, in 1981: Cambridge Reference Sequence. Presumably they picked it because it is short and does not undergo crossover.

About 16.6 kbp:

TODO: many places say "exactly" 16,569, it seems that variable number tandem repeat are either rare or don't occur!