Install and first run by Ciro Santilli 35 Updated +Created
At 7e4cc9e57de76752df0f4e32eca95fb653ea64e4 you basically need to use the Docker image on Ubuntu 21.04 due to pip breaking changes... (not their fault). Perhaps pyenv would solve things, but who has the patience for that?!?!
The Docker setup from README does just work. The image download is a bit tedius, as it requires you to create a GitHub API key as described in the README, but there must be reasons for that.
Once the image is downloaded, you really want to run is from the root of the source tree:
sudo docker run --name=wcm -it -v "$(pwd):/wcEcoli" docker.pkg.github.com/covertlab/wholecellecolirelease/wcm-full
This mounts the host source under /wcEcoli, so you can easily edit and view output images from your host. Once inside Docker we can compile, run the simulation, and analyze results with:
make clean compile &&
python runscripts/manual/runFitter.py &&
python runscripts/manual/runSim.py &&
python runscripts/manual/analysisVariant.py &&
python runscripts/manual/analysisCohort.py &&
python runscripts/manual/analysisMultigen.py &&
python runscripts/manual/analysisSingle.py
The meaning of each of the analysis commands is described at Section "Output overview".
As a Docker refresher, after you stop the container, e.g. by restarting your computer or running sudo docker stop wcm, you can get back into it with:
sudo docker start wcm
sudo docker run -it wcm bash
runscripts/manual/runFitter.py takes about 15 minutes, and it generates files such as reconstruction/ecoli/dataclasses/process/two_component_system.py (related) which is required to run the simulation, it is basically a part of the build.
runSim.py does the main simulation, progress output contains lines of type:
Time (s)  Dry mass     Dry mass      Protein          RNA    Small mol     Expected
              (fg)  fold change  fold change  fold change  fold change  fold change
========  ========  ===========  ===========  ===========  ===========  ===========
    0.00    403.09        1.000        1.000        1.000        1.000        1.000
    0.20    403.18        1.000        1.000        1.000        1.000        1.000
and then it ended on the Lenovo ThinkPad P51 (2017) at:
 2569.18    783.09        1.943        1.910        2.005        1.950        1.963

Simulation finished:
 - Length: 0:42:49
 - Runtime: 0:09:13
when the cell had almost doubled, and presumably divided in 42 minutes of simulated time, which could make sense compared to the 20 under optimal conditions.
Model validation by Ciro Santilli 35 Updated +Created
TODO compare with actual datasetes.
AlphaZero by Ciro Santilli 35 Updated +Created
www.quora.com/Which-chess-engine-would-be-stronger-Alpha-Zero-or-Stockfish-12/answer/Felix-Zaslavskiy explains that it beat Stockfish 8. But then Stockfish was developed further and would start to beat it. We know this because although AlphaZero was closed source, they released the trained artificial neural network, so it was possible to replay AlphaZero at its particular stage of training.
Strong CP problem by Ciro Santilli 35 Updated +Created
Interesting AtomSea & EMBII uploads by Ciro Santilli 35 Updated +Created
tx e3e37ed5c1de2631c147bd39429e42ff634e95b7d72423bc32d6c6b9d8eef8ee (2014-07-01):
For my first official Journal entry I've decided to archive some old poetry. Here are a few of the computational poems I've created using cyphers.
Figure 1.
Shiemaa&Vincent.jpg
. Source.
Message:
"Even if we tried to do it on purpose, never would have we succeeded." My beloved Vincent.
TODO identify Shiemaa and Vincent.
Figure 2.
BikeLady.jpg
. Source. Bike Lady by Allen Lee Vandever. tx 2c4b9497af8c0c0eb9383357b40c3de33dba0b4f481099a32719f2b9036da8e7, block 319927 (2014-09-10)
Figure 3.
Arecibo_message.svg
. Source.
An "artificially" colored visualization of the Arecibo message ripped from Wikipedia: en.wikipedia.org/wiki/File:Arecibo_message.svg (with attribution).
The cool thing about this image is that it highlights the striking parallels between the encoding of the Arecibo message with crypto graffiti, because in both cases people were creating undocumented new ways of communicating with strangers on a new medium in those early blockchain days.
The associated message contains the Arecibo message as ASCII 0's and 1's. When properly cut at the newlines, they draw the message as ASCII art, as the original Arecibo encoding intends, here's a version with the 0's replaced by spaces to make it more readabale:
      1 1 1 1
  1 1     1 1       1
1   1   1   1  1 11  1
1 1 1 1 1 1 1 1  1  1

            11
          11 1
          11 1
          1 1 1
          11111

11    111   11    11
1             11  1
11 1   11   11    11 1
11111 11111 11111 11111

    1                 1

    1                 1
11111             11111

11    11    111   11
1       1         1
11 1    11   111  11 1
11111 11111 11111 11111

    1      11         1
          11
    1     11          1
11111     11      11111
          11
  1        1        1
    1      11       1
    11    11      1
      11   1    11
          11  11
      11   1    11
    11    11      1
    1      1        1
  1       11        1
  1        11        1
  1         1       1
  1       1       1
    1            11
    11        11
  1   111 1 11
  1       1
  1     11111
  1    1 111 1  1 11 11
      1  111  1  111111
1 111    111     11 111
          1 1     111 11
  1      1 1     111111
  1      1 1     11
  1     11 11

  111     1
  111 1 1   1 1 1 1 1 1
  111         1 1 1 1
              1 1
        11111
      111111111
    111       111
    11           11
  11 1         1 11
  11  11       11  11
  1   1 1     1 1   1
  1   1  1   1  1   1
      1   1 1   1
      1    1    1
      1         1
        1  1 1
  1111  11111 1  1111
Figure 4.
He sleeps in a temple.jpg
. tx 460ed23bea89176cdfe18e13fce51ad5386ad8e3e1f7d6f5b4711b3be97b0502, block 360565 (2015-06-12). EMBII claimed on Twitter that he took this photo in Auckland, New Zealand. The shop on the right corner has a sign that starts with "Bo" and searching for "Auckland Bo" gave us the "The body shop" on the corner of Queen Street and Darby Street. Some things changed between 2015 and 2024, notably the bench is gone and the shop on the left corner changed, but we can go back in time in Google Street View to 2015 which further confirms the location.
Figure 5.
PIA17563.jpg
. Source.
Associated message:
NASA: A purple nebula, in honor of #Prince, who passed away today. Image: Crab #Nebula, as Seen by Herschel and #Hubble Image credit: ESA/Herschel/PACS/MESS Key Programme Supernova Remnant Team; #NASA, ESA and Allison Loll/Jeff Hester (Arizona State University) #PIA17563
Figure 6.
Dr_Craig_Wright.jpg
. Source.
The image is present e.g. at: www.kitguru.net/channel/jon-martindale/australian-man-claims-he-is-satoshi-nakamoto-bitcoin-creator/ It was inscribed about two months after Craig publicly claimed that he is Satoshi.
This is a relatively unusual AtomSea & EMBII upload as it does not have the common toplevel transaction, everything, text + image fits into a single transaction. This is perhaps why the image is relatively low resolution to have a smaller size.
Figure 7.
YellowRobot.jpg
. Source.
Photography by EMBII, original art by TODO.
The associated message reads:
Chiharu and I found this little yellow robot while exploring Chicago. It will be covered by tar or eventually removed but this tribute will remain. N 41.880778 E -87.629210
This is one of Ciro's favorite AtomSea & EMBII uploads. This is the cutest thing ever, and perfectly encapsules the "medium as an artform" approach to blockchain art. More Chiharu stalking at: ILoveYouMore.jpg.
At twitter.com/EMBII4U/status/1615389973343268871 EMBII announced that he would be giving off shares of that image on a Bitcoin-based NFT sale system he's making called Sup!?, and in December 2023 gave some shares to Ciro Santilli. Amen.
Other possibly novel EMBII street photography:
Audio:
2-transitive group by Ciro Santilli 35 Updated +Created
Electron transport chain by Ciro Santilli 35 Updated +Created
Number of the beast by Ciro Santilli 35 Updated +Created
ARM Cortex-M by Ciro Santilli 35 Updated +Created
Epyc by Ciro Santilli 35 Updated +Created
Anomalous Zeeman effect by Ciro Santilli 35 Updated +Created
Segmentation by Ciro Santilli 35 Updated +Created
In x86 systems, there may actually be 2 address translation steps:
  • first segmentation
  • then paging
like this:
(logical) ------------------> (linear) ------------> (physical)
             segmentation                 paging
The major difference between paging and segmentation is that:
  • paging splits RAM into equal sized chunks called pages
  • segmentation splits memory into chunks of arbitrary sizes
Paging came after segmentation historically, and largely replaced it for the implementation of virtual memory in modern OSs.
Paging has become so much more popular that support for segmentation was dropped in x86-64 in 64-bit mode, the main mode of operation for new software, where it only exists in compatibility mode, which emulates IA-32.
PSE by Ciro Santilli 35 Updated +Created
Page size extension.
Allows for pages to be 4M ( or 2M if PAE is on ) in length instead of 4K.
PSE is turned on and off via the PSE bit of cr4.
Other architectures by Ciro Santilli 35 Updated +Created
Peter Cordes mentions that some architectures like MIPS leave paging almost completely in the hands of software: a TLB miss runs an OS-supplied function to walk the page tables, and insert the new mapping into the TLB. In such architectures, the OS can use whatever data structure it wants.
Homeothermy by Ciro Santilli 35 Updated +Created
It is quite mind blowing that this is polyphyletic on mammals and birds, what can't parallel evolution achieve??
Figure 1. . Source. Highlights how birds should obviously be classified as reptiles.
Oxford Union by Ciro Santilli 35 Updated +Created
University of Oxford intellectual property policy by Ciro Santilli 35 Updated +Created
For students (who are paying for the university to start with...), they will not claim tutorials linked to courses. But a tutorial that shows university laboratories, it is unclear: www.ox.ac.uk/students/academic/guidance/intellectual-property (archive) This likely includes graduate students, who are also not paid by the university.
For faculty, the university owns everything it seems, to be confirmed.
University of California, Berkeley by Ciro Santilli 35 Updated +Created
The closest site of the University of California to San Francisco. Berkeley, California is a small town on the East of the San Francisco Bay.
Saint Peter by Ciro Santilli 35 Updated +Created
Brother of andrew the Apostle, called by Jesus in fishers of men. Born Simon, but Jesus renamed him to Peter, thus the weird "Simon called Peter" way he is referred to as in some versions of the Bible.

Unlisted articles are being shown, click here to show only listed articles.