This was the first full scale nuclear reactor in the world, and was brought up slowly to test it out.
A nuclear reactor made to produce specific isotopes rather than just consume fissile material to produce electrical power. The most notably application being to produce Plutonium-239 for nuclear weapons from Uranium-238 being irradiated from Uranium-235-created fission.
The B Reactor of the facility produced the plutonium used for Trinity and Fat Man, and then for many more thousand bombs during the Cold War. More precisely, this was done at
Located in Washington, in a dry place the middle of the mountainous areas of the Western United States, where basically no one lives. The Columbia river is however nearby, that river is quite large, and provided the water needed by their activities, notably for cooling the nuclear reactors. It is worth it having look on Google Maps to get a feel for the region.
Unlike many other such laboratories, this one did not become a United States Department of Energy national laboratories. It was likely just too polluted.
Bibliography:
Because they interact weakly with matter and mostly just escape out of nuclear reactors, you can likely locate all nuclear reactors on Earth by measuring neutrino flows:The CIA must love that shit, they must have had it years prior to this public paper.