1962 software
"1962 software" generally refers to a specific class of software or a development environment that emulates or is inspired by the programming practices and technologies from around the year 1962. However, it's not a commonly used term in the software industry.
1963 software
"1963 Software" typically refers to a software development effort or company that specializes in software engineering and related technologies. It could also involve the use of or development of software that is inspired by, or based on, programming languages and systems from 1963 or the early computing era, which might include languages such as FORTRAN or LISP, both of which were introduced around that time.
Nonribosomal peptide
Nonribosomal peptides are a class of peptides that are synthesized in cells by nonribosomal peptide synthetases (NRPSs), which are large multi-modular enzyme complexes. Unlike ribosomal peptides, which are produced through the classical ribosomal translation of messenger RNA, nonribosomal peptides are synthesized from amino acids in a sequence that is determined by the NRPSs, not by mRNA templates. This allows for a greater diversity of structures and modifications.
Nuclear gene
A nuclear gene is a segment of DNA located within the nucleus of a eukaryotic cell, which encodes information for the synthesis of proteins or functional RNA molecules. Nuclear genes are distinct from mitochondrial or plastid genes, which are found in mitochondria and chloroplasts, respectively. Here are some key points regarding nuclear genes: 1. **Structure**: Nuclear genes are composed of exons (coding regions) and introns (non-coding regions).
Nucleic acid hybridization
Nucleic acid hybridization is a molecular biology technique used to identify, analyze, or manipulate nucleic acids (DNA or RNA) by allowing complementary strands to bind together. This process occurs when two single strands of nucleic acids (either DNA or RNA) come together and form a double-stranded molecule through base pairing.
Nucleic acid sequence
A nucleic acid sequence is a series of nucleotides, which are the basic building blocks of nucleic acids like DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). Each nucleotide consists of a sugar, a phosphate group, and a nitrogenous base. The sequence of these nucleotides determines the genetic information carried by the nucleic acid.
Primer walking
Primer walking is a technique used in molecular biology, particularly in the context of DNA sequencing and the analysis of specific DNA regions. It involves designing and synthesizing a series of overlapping primers that anneal to a template DNA strand. This method allows for the sequential amplification of DNA segments using polymerase chain reaction (PCR) or similar techniques, facilitating the generation of longer contiguous reads of DNA.
Protein Information Resource
The Protein Information Resource (PIR) is a publicly accessible database and bioinformatics resource that focuses on the collection, analysis, and dissemination of information regarding protein sequences and their functions. Established in the 1980s, PIR provides a wealth of data related to protein sequences, structures, function, and annotations. Key features of the Protein Information Resource include: 1. **Database**: PIR maintains a comprehensive database of protein sequences, including those from various organisms.
Protein Misfolding Cyclic Amplification (PMCA) is a laboratory technique used to amplify misfolded proteins, particularly prions, which are infectious agents composed primarily of protein. This method takes advantage of the unique property of prion proteins to induce misfolding in normally folded proteins, allowing for the detection and study of these pathogenic forms.
RK2 plasmid
The RK2 plasmid is a well-studied example of a conjugative plasmid, which is a small, circular piece of DNA that replicates independently of the chromosomal DNA in a cell. RK2 is particularly notable for its role in the transfer of genetic material between bacteria, a process known as horizontal gene transfer. It was originally derived from the bacterium *Ralstonia solanacearum*.
1969 software
1969 Software is a software company that focuses on developing applications and systems primarily designed for the manufacturing and industrial sectors. The company is known for creating solutions that help businesses improve efficiency, optimize workflows, and manage operations more effectively. One of their notable products is a software suite dedicated to the needs of manufacturers, which may include features for project management, quality control, inventory management, and other manufacturing processes.
Paired-end tag
A paired-end tag (PET) is a feature used in DNA sequencing, particularly in next-generation sequencing (NGS) technologies. Paired-end sequencing involves reading from both ends of a DNA fragment, producing two reads (tags) from each fragment that are then used to generate data for genomic analysis.
Paritaprevir
Paritaprevir is an antiviral medication used primarily in the treatment of hepatitis C virus (HCV) infection. It is a direct-acting antiviral (DAA) that acts as a protease inhibitor, specifically targeting the NS3/4A protease enzyme, which is crucial for the replication of the hepatitis C virus.
Partial cloning
Partial cloning refers to the technique of creating a copy of a dataset or a database where only a subset of the original data is replicated or cloned. This method is typically used to manage data more efficiently, streamline testing and development processes, or reduce storage costs by including only relevant data for specific applications or analyses.
Peptide computing
Peptide computing is an emerging field that combines principles from computer science and biochemistry, leveraging peptides—short chains of amino acids—to perform computational tasks. This approach is inspired by the unique properties of peptides and their ability to interact and bind with various molecules, facilitating complex biological processes and enabling novel computational paradigms.
Peptidomimetic
Peptidomimetics are compounds that mimic the structure and function of peptides, which are short chains of amino acids. These synthetic analogs are designed to replicate specific biological activities of natural peptides, such as hormone action, enzyme inhibition, or receptor binding, while often having enhanced stability, bioavailability, and resistance to enzymatic degradation. The design of peptidomimetics involves modifying the peptide structure to improve its pharmacological properties.
Phage display
Phage display is a molecular technique that allows for the identification and characterization of proteins, peptides, or antibodies by expressing them on the surface of bacteriophages (viruses that infect bacteria). This technique enables researchers to study interactions between proteins, identify binding partners, and explore various biological processes. Here's how phage display works in more detail: 1. **Construction of a Library**: A diverse library of DNA sequences encoding different peptides or proteins is constructed.
Phagemid
A phagemid is a type of hybrid vector used in molecular biology that combines elements of both plasmids and bacteriophages (phages). Phagemids are typically designed to make it easier to clone and express genes in bacterial systems, particularly in the context of recombinant DNA technology.
Pharming (genetics)
Pharming in genetics refers to the process of using genetically modified organisms (GMOs), typically plants or animals, to produce pharmaceuticals or other beneficial substances. This technique involves the integration of genes that code for specific therapeutic proteins or other bioproducts into the genome of the organism. The organisms are then cultivated under controlled conditions, allowing them to produce the desired therapeutic compounds in their tissues or secretions.
Photodegradation
Photodegradation is a process by which chemical compounds break down when exposed to light, particularly ultraviolet (UV) radiation. This phenomenon is important in various fields, including environmental science, materials science, and photochemistry, as it affects the stability and lifespan of materials, the degradation of pollutants, and the breakdown of organic compounds. In the context of the environment, photodegradation plays a significant role in the natural degradation of pollutants such as plastics, pesticides, and organic waste.