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If and is differentiable, the chain rule gives . Taking antiderivatives gives the substitution ruleWriting and records this chain rule in reverse. For a continuous function and continuously differentiable , the fundamental theorem of calculus gives the corresponding definite integral identityThe order of the transformed endpoints determines the sign. For example, . If the substitution is used in the opposite direction by solving as a function of , one must restrict to a suitable inverse branch; the tangent half-angle substitution illustrates why separate branches can be necessary even when the original integrand is smooth. The general change of variables formula extends substitution to higher dimensions.