KCNK12, also known as TREK-2 (Twik-Related K+ Channel 2), is a gene that encodes a protein belonging to the two-pore domain potassium channel (K2P) family. These channels are involved in the maintenance of the resting membrane potential and the regulation of neuronal excitability. KCNK12 functions primarily as a background potassium channel, which means it contributes to the passive flow of potassium ions across the cell membrane.

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