 Noncovalent interaction

A noncovalent interaction is an attraction or repulsion between chemical groups that does not require forming a new ordinary covalent bond between them. In biochemistry, examples include hydrogen bonds, electrostatic interactions and Van der Waals forces, acting either between molecules or within one molecule. These interactions help stabilize biomolecular structures and enable molecular recognition.^[ref]

The Lennard-Jones potential gives a simple distance-dependent example:The steep positive term models short-range repulsion; the negative term supplies attraction. Here $r$ is separation, $ϵ$ sets the energy scale and $\sigma$ sets a length scale.^[ref]

Substitution gives $U(\sigma )=0$. At $r=2^{1/6}\sigma$, the sixth-power term is $1/2$ and the twelfth-power term is $1/4$, so $U=-ϵ$. A pair can therefore have a preferred separation without acquiring a new covalent bond. Bringing the groups still closer eventually raises the energy sharply.

This is an illustrative pair model, not a complete description of every hydrogen bond or protein-binding event. Real molecular association also depends on geometry, other contacts and the surrounding solvent. Its central lesson is that noncovalent does not mean energetically negligible or independent of distance.