Notch signalling is a contact-dependent signalling pathway in which a ligand on one cell activates a receptor on another. Proteolytic processing releases an intracellular receptor fragment that can enter the cell nucleus and participate in transcription control. receptor processing therefore links a local contact to a nuclear response. During vertebrate somitogenesis, coupling through Notch signalling can coordinate neighbouring oscillators without being identical to their intracellular oscillation mechanism. [ref]
https://www.nature.com/articles/30756. Schroeter, Kisslinger and Kopan, 1998, ligand-induced proteolytic release and transcriptional signalling
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