PAR-6 is a polarity scaffold protein that interacts with an atypical protein kinase C and the small GTPase Cdc42. These interactions connect a nucleotide-dependent signal to localized kinase activity and cortical organization. Family members and developmental contexts differ, so a general complex architecture does not establish an identical role in every tissue. Positioning the complex helps cells distinguish one surface domain from another. [ref]
NCBI Gene by the National Library of Medicine. Homo sapiens, PARD6A record, Summary and linked functional evidence
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