Solution

ID: past-exam-of-the-biological-physics-course-of-the-university-of-oxford/2015/2/d/solution

Fast ion-channel inactivation would reduce the outward potassium electric current just when it normally repolarizes the axon. Since , a reduction of positive makes the falling slope less negative. With other mechanisms unchanged, the action potential is generally broader and its after-hyperpolarization is weaker. A plateau or slow return is possible until sodium ion-channel inactivation, leakage, or another outward conductance restores the resting membrane potential. The precise trace depends on those remaining currents; rapid potassium inactivation alone does not determine a unique waveform.
Figure 1.
Original schematic action potential broadening and two-state relaxation and sequential-transition probability densities
. Details.
The left panel is a qualitative sketch of this comparison, not a fit or a reconstruction of the missing historical recording.

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