Ion-channel inactivation is loss of availability for conduction, distinct from simply closing an otherwise activatable ion channel. Recovery depends on channel type and membrane potential; incomplete recovery of sodium-selective voltage-gated ion channels contributes to a neuronal refractory period.
An availability change associated with the outer pore and selectivity filter of certain potassium ion channels. Its kinetics and structural origin differ from ball-and-chain inactivation, although the two processes can interact.
A tethered intracellular particle blocks an open ion channel from the cytoplasmic side. In classical Shaker-type channels the particle is N-terminal: removing it suppresses fast inactivation, while cytoplasmic application of a corresponding peptide can restore block. The pore-blocking mechanism differs from ordinary activation-gate closure.
Articles by others on the same topic
There are currently no matching articles.