Solution

ID: past-exam-of-the-mathematics-course-of-the-university-of-cambridge/2005/iii/paper-45/2/b/solution

Let the first cousins be , with parents and respectively, where are full siblings and have no ancestral relationship to one another or to that sibling family. To compute , choose one allele copy from each cousin. They originate from and with probability . All other parental combinations have zero kinship coefficient under the otherwise outbred pedigree assumption. Hence
The two gene copies within a child of are random transmissions from these parents. They are identical by descent precisely in the event defining parental kinship, so the child's inbreeding coefficient is
For a direct ancestral-path check, there are two shared noninbred grandparents. Through either grandparent, the two cousin-to-grandparent paths have two meioses each, and matching the ancestral grandparental copy supplies a further factor . Each contributes , giving the same first-cousin inbreeding coefficient. Additional ancestral relationships or inbred grandparents would change the result.

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