 Solution

TODO: Biology deferred at the user's request: biological tracer behavior and clinical PET applications.

The generic physics of positron emission tomography uses electron-positron annihilation. A slowly moving electron-positron pair predominantly produces two nearly opposite photons with energy close to $m_e{c}^2=511\mathrm{keV}$ each. A ring of detectors records approximately simultaneous interactions; a coincidence identifies a coincidence line of response along which an annihilation could have occurred. Finite Positron travel before annihilation and nonzero pair momentum limit how directly this line identifies the original emission location.

Many such measurements constrain an emission distribution through a tomography model. Attenuation, scattered coincidences, unrelated random coincidences, finite detector resolution and dead time alter the observed counts and require calibration or modeling. With useful time-of-flight information, the arrival-time difference further localizes position along the line: a timing uncertainty $\delta t$ corresponds to a position scale $c\delta t/2$. The coincidence data therefore provide spatial constraints, rather than each event directly supplying a complete three-dimensional image point.