Solution

ID: past-exam-of-the-stochastic-modelling-of-biological-processes-course-of-the-university-of-oxford/2023/2/b/solution

At the transverse coordinates are independent Brownian motions with diffusion coefficient . The cylinder is infinitely long, so the axial coordinate cannot affect its first contact time. By rotational invariance of Brownian motion, the mean first-passage time depends only on the transverse radius .
The Kolmogorov backward equation for a mean first-passage time is . Here , so the radial boundary value problem is
The absorbing boundary condition for a diffusion is imposed on the circular cross-section. At , the solution must extend smoothly over the axis. Multiplying by and integrating gives
Smoothness at the axis excludes the logarithm term, and fixes . Consequently
This also verifies the finiteness assumption behind the Kolmogorov backward equation. Let be the first contact time and apply the stopped Itô formula to the bounded nonnegative function just obtained. Its bounded derivatives on the disk make the stopped stochastic integral a martingale, giving
By monotone convergence, has finite expected value; continuity and dominated convergence then make the final term vanish as . Hence . In particular, the mean first-passage time is on the axis and tends to zero at the adsorbing wall.

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